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KMID : 0043319920150010095
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Archives of Pharmacal Research
1992 Volume.15 No. 1 p.95 ~ p.98
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Presence of Acetylcholine-like Substance(s) in Sesamum indicum
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Anwar-ul HG
Khalid A
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Abstract
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Alcoholic extract of seeds of Sesamum indicum (SI, 1-30mg/kg) caused hypotensive action in anesthetized rats. Heart rate was also decreased at slightly higher doses (10-30mg/kg). Pretreatment with atropine (2mg/kg) abolished these cardiovascular responses. In isolated spontaneously beating atria from guinea-pigs, SI caused decrease in force and rate of atrial contractions. In isolated guinea-pig ileum and rat uterus, SI (100-1000 ug/ml produced contractile responses. All these actions of SI were abolished in the presence of atropine (1mcM). These results indicate that alcoholic extract of seeds of Sesamum indicum contains acetylcholine-like constituent(s) which explains some of the folkloric uses of plant.
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